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Target
Histone deacetylase 1
Ligand
BDBM50556949
Substrate
n/a
Meas. Tech.
ChEMBL_2272459
IC50
2226±n/a nM
Citation
 Wang, J; Gong, F; Liang, T; Xie, Z; Yang, Y; Cao, C; Gao, J; Lu, T; Chen, X A review of synthetic bioactive tetrahydro-?-carbolines: A medicinal chemistry perspective. Eur J Med Chem 225:0 (2021) [PubMed]
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50556949
Synonyms:
CHEMBL4745420
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O3
Mol. Mass.:
413.897
SMILES:
ONC(=O)Cc1ccc(OCCCn2c3CNCCc3c3cccc(Cl)c23)cc1
Structure:
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