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Target
Histone deacetylase 1
Ligand
BDBM50608063
Substrate
n/a
Meas. Tech.
ChEMBL_2272459
IC50
197±n/a nM
Citation
 Wang, J; Gong, F; Liang, T; Xie, Z; Yang, Y; Cao, C; Gao, J; Lu, T; Chen, X A review of synthetic bioactive tetrahydro-?-carbolines: A medicinal chemistry perspective. Eur J Med Chem 225:0 (2021) [PubMed]
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50608063
Synonyms:
CHEMBL5269889
Type:
Small organic molecule
Emp. Form.:
C33H33N7O6
Mol. Mass.:
623.6584
SMILES:
[H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(CC1CCN(CC1)c1ncc(CC(=O)NO)cn1)C2=O)c1ccc2OCOc2c1 |r|
Structure:
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