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Target
Histone deacetylase 2b
Ligand
BDBM50195603
Substrate
n/a
Meas. Tech.
ChEMBL_416717 (CHEMBL909983)
IC50
62±n/a nM
Citation
 Mai, A; Massa, S; Rotili, D; Simeoni, S; Ragno, R; Botta, G; Nebbioso, A; Miceli, M; Altucci, L; Brosch, G Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J Med Chem 49:6046-56 (2006) [PubMed]  Article
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Zea mays
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
  
Inhibitor
Name:
BDBM50195603
Synonyms:
CHEMBL217449 | N-hydroxy-6-(3,4-dihydro-4-oxo-6-(1-phenyl-1-cyclopropyl)-2-pyrimidinylthio)hexanamide
Type:
Small organic molecule
Emp. Form.:
C19H23N3O3S
Mol. Mass.:
373.469
SMILES:
ONC(=O)CCCCCSc1nc(cc(=O)[nH]1)C1(CC1)c1ccccc1
Structure:
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