Reaction Details  Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50608206
Substrate
n/a
Meas. Tech.
ChEMBL_2273258
Ki
448±n/a nM
Citation
 Jacobson, KA; Salmaso, V; Suresh, RR; Tosh, DK Expanding the repertoire of methanocarba nucleosides from purinergic signaling to diverse targets. RSC Med Chem 12:1808-1825 (2021) [PubMed]
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50608206
Synonyms:
CHEMBL5201437
Type:
Small organic molecule
Emp. Form.:
C22H21ClN4O4S
Mol. Mass.:
472.945
SMILES:
[H][C@]12C[C@@]1([C@@H](O)[C@@H](O)[C@@H]2n1ccc2c(NC)nc(nc12)C#Cc1ccc(Cl)s1)C(=O)OCC |r|
Structure:
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