Reaction Details  Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50196007
Substrate
n/a
Meas. Tech.
ChEMBL_431897 (CHEMBL917395)
Ki
21.4±n/a nM
Citation
 Giorgi, I; Bianucci, AM; Biagi, G; Livi, O; Scartoni, V; Leonardi, M; Pietra, D; Coi, A; Massarelli, I; Nofal, FA; Fiamingo, FL; Anastasi, P; Giannini, G Synthesis, biological activity and molecular modelling of new trisubstituted 8-azaadenines with high affinity for A1 adenosine receptors. Eur J Med Chem 42:1-9 (2007) [PubMed]  Article
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36602.99
Organism:
BOVINE
Description:
ADENOSINE 0 BOVINE::P28190
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTPRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYMVYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPVDEDAPAERPDD
  
Inhibitor
Name:
BDBM50196007
Synonyms:
3-(3-benzyl-5-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ylamino)propan-1-ol | CHEMBL226562
Type:
Small organic molecule
Emp. Form.:
C20H20N6O
Mol. Mass.:
360.4124
SMILES:
OCCCNc1nc(nc2n(Cc3ccccc3)nnc12)-c1ccccc1
Structure:
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