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Target
Kallikrein-1
Ligand
BDBM463332
Substrate
n/a
Meas. Tech.
ChEMBL_2273945
IC50
2.9±n/a nM
Citation
 Xie, Z; Li, Z; Shao, Y; Liao, C Discovery and development of plasma kallikrein inhibitors for multiple diseases. Eur J Med Chem 190:0 (2020) [PubMed]
Target
Name:
Kallikrein-1
Synonyms:
KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:
Enzyme
Mol. Mass.:
28874.69
Organism:
Homo sapiens (Human)
Description:
P06870
Residue:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
  
Inhibitor
Name:
BDBM463332
Synonyms:
3-Amino-1-[(4-(2-oxo-2H-pyridin-1-ylmethyl)-benzyl]-1H-pyrazole-4-carboxylic acid [2-(3-chloro-phenoxy)-ethyl]-amide | US10781181, Example 1
Type:
Small organic molecule
Emp. Form.:
C25H24ClN5O3
Mol. Mass.:
477.943
SMILES:
Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCCOc1cccc(Cl)c1
Structure:
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