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Target
DNA polymerase I, thermostable
Ligand
BDBM50196496
Substrate
n/a
Meas. Tech.
ChEMBL_432004 (CHEMBL918788)
IC50
5800±n/a nM
Citation
 Sissi, C; Lucatello, L; Paul Krapcho, A; Maloney, DJ; Boxer, MB; Camarasa, MV; Pezzoni, G; Menta, E; Palumbo, M Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition. Bioorg Med Chem 15:555-62 (2006) [PubMed]  Article
Target
Name:
DNA polymerase I, thermostable
Synonyms:
DNA polymerase I, thermostable | DPO1_THEAQ | Taq polymerase 1 | pol1 | polA
Type:
PROTEIN
Mol. Mass.:
93906.95
Organism:
Thermus aquaticus
Description:
ChEMBL_1289218
Residue:
832
Sequence:
MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGDAVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLKLSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
  
Inhibitor
Name:
BDBM50196496
Synonyms:
2,7-bis-[2-(2-hydroxy-ethylamino)-ethyl]-benzo[lmn][3,8]phenanthroline-1,3,6,8-tetraone | CHEMBL225209
Type:
Small organic molecule
Emp. Form.:
C22H24N4O6
Mol. Mass.:
440.4492
SMILES:
OCCNCCn1c(=O)c2ccc3c4c(ccc(c24)c1=O)c(=O)n(CCNCCO)c3=O
Structure:
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