Reaction Details  Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50094505
Substrate
n/a
Meas. Tech.
ChEMBL_2275361
Ki
0.520000±n/a nM
Citation
 Giorgioni, G; Del Bello, F; Pavleti?, P; Quaglia, W; Botticelli, L; Cifani, C; Micioni Di Bonaventura, E; Micioni Di Bonaventura, MV; Piergentili, A Recent findings leading to the discovery of selective dopamine D Eur J Med Chem 212:0 (2021) [PubMed]
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50094505
Synonyms:
2-((4-phenylpiperazin-1-yl)methyl)-1H-indole-5-carbonitrile | 2-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole-5-carbonitrile | CHEMBL140099
Type:
Small organic molecule
Emp. Form.:
C20H20N4
Mol. Mass.:
316.3996
SMILES:
N#Cc1ccc2[nH]c(CN3CCN(CC3)c3ccccc3)cc2c1
Structure:
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