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Target
D(4) dopamine receptor
Ligand
BDBM50092051
Substrate
n/a
Meas. Tech.
ChEMBL_2275371
Ki
4.0±n/a nM
Citation
 Giorgioni, G; Del Bello, F; Pavleti?, P; Quaglia, W; Botticelli, L; Cifani, C; Micioni Di Bonaventura, E; Micioni Di Bonaventura, MV; Piergentili, A Recent findings leading to the discovery of selective dopamine D Eur J Med Chem 212:0 (2021) [PubMed]
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50092051
Synonyms:
3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one | CHEMBL305276
Type:
Small organic molecule
Emp. Form.:
C21H24ClN3O
Mol. Mass.:
369.888
SMILES:
CN1C(=O)C(Cc2ccccc12)N1CCN(Cc2ccc(Cl)cc2)CC1
Structure:
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