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Target
Histone deacetylase 1
Ligand
BDBM50196597
Substrate
n/a
Meas. Tech.
ChEMBL_422105 (CHEMBL907102)
IC50
15±n/a nM
Citation
 Marson, CM; Mahadevan, T; Dines, J; Sengmany, S; Morrell, JM; Alao, JP; Joel, SP; Vigushin, DM; Charles Coombes, R Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase. Bioorg Med Chem Lett 17:136-41 (2006) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50196597
Synonyms:
CHEMBL384714 | N-hydroxy-7-(4-(methyl(pyridin-4-ylmethyl)amino)phenoxy)heptanamide
Type:
Small organic molecule
Emp. Form.:
C20H27N3O3
Mol. Mass.:
357.4467
SMILES:
CN(Cc1ccncc1)c1ccc(OCCCCCCC(=O)NO)cc1
Structure:
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