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Target
Protein mono-ADP-ribosyltransferase PARP16
Ligand
BDBM50609916
Substrate
n/a
Meas. Tech.
ChEMBL_2279923
IC50
362±n/a nM
Citation
 Zhang, J; Gao, Y; Zhang, Z; Zhao, J; Jia, W; Xia, C; Wang, F; Liu, T Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment. J Med Chem 65:16099-16127 (2022) [PubMed]
Target
Name:
Protein mono-ADP-ribosyltransferase PARP16
Synonyms:
2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 15 | ARTD15 | C15orf30 | Mono [ADP-ribose] polymerase PARP16 | PAR16_HUMAN | PARP-16 | PARP16 | Poly [ADP-ribose] polymerase 16 | Synonyms=ARTD15
Type:
PROTEIN
Mol. Mass.:
36398.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117586
Residue:
322
Sequence:
MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQTKKKDSKEIDRRRARIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRASSQLSWFSSHWFTVMISLYLLLLLIVSVINSSAFQHFWNRAKR
  
Inhibitor
Name:
BDBM50609916
Synonyms:
CHEMBL5284069
Type:
Small organic molecule
Emp. Form.:
C15H12Cl2N2O2
Mol. Mass.:
323.174
SMILES:
O[C@@H]1C(CNC(=O)c2cc(Cl)c(Cl)cc12)c1ccccn1 |r|
Structure:
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