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Target
Protein mono-ADP-ribosyltransferase PARP3
Ligand
BDBM50609916
Substrate
n/a
Meas. Tech.
ChEMBL_2279924
IC50
74100±n/a nM
Citation
 Zhang, J; Gao, Y; Zhang, Z; Zhao, J; Jia, W; Xia, C; Wang, F; Liu, T Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment. J Med Chem 65:16099-16127 (2022) [PubMed]
Target
Name:
Protein mono-ADP-ribosyltransferase PARP3
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT-3 | ADPRT3 | ADPRTL3 | ARTD3 | IRT1 | NAD(+) ADP-ribosyltransferase 3 | PARP-3 | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly[ADP-ribose] synthase 3 | hPARP-3 | pADPRT-3
Type:
PROTEIN
Mol. Mass.:
60091.40
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109545
Residue:
533
Sequence:
MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
  
Inhibitor
Name:
BDBM50609916
Synonyms:
CHEMBL5284069
Type:
Small organic molecule
Emp. Form.:
C15H12Cl2N2O2
Mol. Mass.:
323.174
SMILES:
O[C@@H]1C(CNC(=O)c2cc(Cl)c(Cl)cc12)c1ccccn1 |r|
Structure:
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