Reaction Details  Report a problem with these data
Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50591456
Substrate
n/a
Meas. Tech.
ChEMBL_2280298
IC50
148±n/a nM
Citation
 Orsi, DL; Ferrara, SJ; Siegel, S; Friberg, A; Bouché, L; Pook, E; Lienau, P; Bluck, JP; Lemke, CT; Akcay, G; Stellfeld, T; Meyer, H; Pütter, V; Holton, SJ; Korr, D; Jerchel-Furau, I; Pantelidou, C; Strathdee, CA; Meyerson, M; Eis, K; Goldstein, JT Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorg Med Chem 78:0 (2023) [PubMed]
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
Nr1c3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG_MOUSE | Pparg
Type:
PROTEIN
Mol. Mass.:
57593.55
Organism:
Mus musculus
Description:
ChEMBL_1453700
Residue:
505
Sequence:
MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50591456
Synonyms:
CHEMBL5207130
Type:
Small organic molecule
Emp. Form.:
C22H16ClN3O4
Mol. Mass.:
421.833
SMILES:
CCc1ccc(cc1)-c1nc2cc(NC(=O)c3cc(ccc3Cl)[N+]([O-])=O)ccc2o1
Structure:
Search PDB for entries with ligand similarity: