Reaction Details  Report a problem with these data
Target
Apoptosis regulator BAX
Ligand
BDBM50610525
Substrate
n/a
Meas. Tech.
ChEMBL_2281422
Kd
255±n/a nM
Citation
 Pogmore, JP; Uehling, D; Andrews, DW Pharmacological Targeting of Executioner Proteins: Controlling Life and Death. J Med Chem 64:5276-5290 (2021) [PubMed]
Target
Name:
Apoptosis regulator BAX
Synonyms:
Apoptosis regulator BAX | BAX | BAX_HUMAN | BCL2L4 | Bcl-2-like protein 4 | Bcl2-L-4
Type:
PROTEIN
Mol. Mass.:
21181.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100916
Residue:
192
Sequence:
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
  
Inhibitor
Name:
BDBM50610525
Synonyms:
CHEMBL4578793
Type:
Small organic molecule
Emp. Form.:
C25H26N4O
Mol. Mass.:
398.5001
SMILES:
CN1CCN(CC1)C(c1c(-c2ccccc2)n(O)c2ccccc12)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: