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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50122956
Substrate
n/a
Meas. Tech.
ChEMBL_2286006
IC50
2.4±n/a nM
Citation
 Kousaxidis, A; Petrou, A; Lavrentaki, V; Fesatidou, M; Nicolaou, I; Geronikaki, A Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus. Eur J Med Chem 207:0 (2020) [PubMed]
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50122956
Synonyms:
CHEMBL138065 | [2,4-Bis-(4-methoxy-benzoyl)-pyrrol-1-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C22H19NO6
Mol. Mass.:
393.3894
SMILES:
COc1ccc(cc1)C(=O)c1cc(C(=O)c2ccc(OC)cc2)n(CC(O)=O)c1
Structure:
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