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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50612081
Substrate
n/a
Meas. Tech.
ChEMBL_2286020
IC50
60±n/a nM
Citation
 Kousaxidis, A; Petrou, A; Lavrentaki, V; Fesatidou, M; Nicolaou, I; Geronikaki, A Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus. Eur J Med Chem 207:0 (2020) [PubMed]
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50612081
Synonyms:
CHEMBL5271166
Type:
Small organic molecule
Emp. Form.:
C29H22N4O4S2
Mol. Mass.:
554.639
SMILES:
Cc1cccc(c1)-c1nn(cc1\C=C1/SC(=S)N(C1=O)c1ccc(cc1)C(=O)NCC(O)=O)-c1ccccc1
Structure:
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