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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM13606
Substrate
n/a
Meas. Tech.
ChEMBL_2286039
Ki
5000±n/a nM
Citation
 Kousaxidis, A; Petrou, A; Lavrentaki, V; Fesatidou, M; Nicolaou, I; Geronikaki, A Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus. Eur J Med Chem 207:0 (2020) [PubMed]
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_RAT | PTP-1B | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Ptpn1 | Tyrosine-protein phosphatase, non-receptor type 1
Type:
Enzyme
Mol. Mass.:
49669.91
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
432
Sequence:
MEMEKEFEQIDKAGNWAAIYQDIRHEASDFPCRIAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQYWPQKEEKEMVFDDTNLKLTLISEDVKSYYTVRQLELENLATQEAREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHVPPPPRPPKRTLEPHNGKCKELFSNHQWVSEESCEDEDILAREESRAPSIAVHSMSSMSQDTEVRKRMVGGGLQSAQASVPTEEELSPTEEEQKAHRPVHWKPFLVNVCMATALATGAYLCYRVCFH
  
Inhibitor
Name:
BDBM13606
Synonyms:
(3S)-3-{[(1S)-1-{[(1S)-1-carbamoylpentyl]carbamoyl}-2-[4-(sulfooxy)phenyl]ethyl]carbamoyl}-3-acetamidopropanoic acid | CHEMBL175257 | Compound I | N-acetyl-Asp-Tyr(SO3H)-Nle-NH2 | sulfotyrosyl tripeptide I
Type:
Small organic molecule
Emp. Form.:
C21H30N4O10S
Mol. Mass.:
530.549
SMILES:
CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(N)=O |r|
Structure:
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