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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50612109
Substrate
n/a
Meas. Tech.
ChEMBL_2286058
IC50
5.0±n/a nM
Citation
 Kousaxidis, A; Petrou, A; Lavrentaki, V; Fesatidou, M; Nicolaou, I; Geronikaki, A Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus. Eur J Med Chem 207:0 (2020) [PubMed]
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50612109
Synonyms:
CHEMBL5275241
Type:
Small organic molecule
Emp. Form.:
C37H25Br2F4N3O7P2
Mol. Mass.:
921.359
SMILES:
OP(O)(=O)C(F)(F)c1cc2ccc(cc2cc1Br)C(Cc1ccc2cc(Br)c(cc2c1)C(F)(F)P(O)(O)=O)(C(=O)c1ccccc1)n1nnc2ccccc12
Structure:
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