Reaction Details  Report a problem with these data
Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50612568
Substrate
n/a
Meas. Tech.
ChEMBL_2288893
IC50
1680±n/a nM
Citation
 Provensi, G; Costa, A; Rani, B; Becagli, MV; Vaiano, F; Passani, MB; Tanini, D; Capperucci, A; Carradori, S; Petzer, JP; Petzer, A; Vullo, D; Costantino, G; Blandina, P; Angeli, A; Supuran, CT New ?-arylchalcogeno amines with procognitive properties targeting Carbonic Anhydrases and Monoamine Oxidases. Eur J Med Chem 244:0 (2022) [PubMed]
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM50612568
Synonyms:
CHEMBL5281498
Type:
Small organic molecule
Emp. Form.:
C11H17NSe
Mol. Mass.:
242.22
SMILES:
[#6]-[#6](-[#7])-[#6][Se;v2]c1c(-[#6])cccc1-[#6]
Structure:
Search PDB for entries with ligand similarity: