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Target
5'-AMP-activated protein kinase subunit beta-2
Ligand
BDBM4814
Substrate
n/a
Meas. Tech.
ChEMBL_2289885
IC50
62±n/a nM
Citation
 Ye, W; Fan, C; Fu, K; Wang, X; Lin, J; Nian, S; Liu, C; Zhou, W The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance. Eur J Med Chem 244:0 (2022) [PubMed]
Target
Name:
5'-AMP-activated protein kinase subunit beta-2
Synonyms:
AAKB2_RAT | AMPK subunit beta-2 | Prkab2
Type:
PROTEIN
Mol. Mass.:
30226.28
Organism:
Rattus norvegicus
Description:
ChEMBL_119733
Residue:
271
Sequence:
MGNTTSERVSGERHGAKAARAEGGGHGPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVPWQQDLDDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDLSSSPPGPYGQEMYVFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSTKDSVMVLSATHRYKKKYVTTLLYKPI
  
Inhibitor
Name:
BDBM4814
Synonyms:
CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide | N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide | SU11248 | SUNITINIB | SUNITINIB MALATE | US10464902, Sunitinib | US20240058459, Compound Sunit-inib | US9163010, Sunitinib | US9914707, SU11248
Type:
Small organic molecule
Emp. Form.:
C22H27FN4O2
Mol. Mass.:
398.4738
SMILES:
CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Structure:
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