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Target
Ubiquitin carboxyl-terminal hydrolase 21
Ligand
BDBM50612985
Substrate
n/a
Meas. Tech.
ChEMBL_2290625
IC50
21480±n/a nM
Citation
 Göricke, F; Vu, V; Smith, L; Scheib, U; Böhm, R; Akkilic, N; Wohlfahrt, G; Weiske, J; Bömer, U; Brzezinka, K; Lindner, N; Lienau, P; Gradl, S; Beck, H; Brown, PJ; Santhakumar, V; Vedadi, M; Barsyte-Lovejoy, D; Arrowsmith, CH; Schmees, N; Petersen, K Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. J Med Chem 66:3431-3447 (2023) [PubMed]
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 21
Synonyms:
Deubiquitinating enzyme 21 | UBP21_HUMAN | USP21 | USP23 | Ubiquitin thioesterase 21 | Ubiquitin-specific-processing protease 21
Type:
PROTEIN
Mol. Mass.:
62692.84
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105198
Residue:
565
Sequence:
MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPDERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASHGSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL
  
Inhibitor
Name:
BDBM50612985
Synonyms:
CHEMBL5284472
Type:
Small organic molecule
Emp. Form.:
C22H27N5O4S
Mol. Mass.:
457.546
SMILES:
COC[C@@H](NC(=O)C1(CCCCC1)OC)C(=O)Nc1nnc(Cc2ccc(cc2)C#N)s1 |r|
Structure:
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