Target
Taste receptor type 2 member 14
Ligand
BDBM50613013
Substrate
n/a
Meas. Tech.
ChEMBL_2290791
EC50
1800±n/a nM
Citation
 Waterloo, LHübner, HFierro, FPfeiffer, TBrox, RLöber, SWeikert, DNiv, MYGmeiner, P Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14. J Med Chem 66:3499-3521 (2023) [PubMed]
Target
Name:
Taste receptor type 2 member 14
Synonyms:
T2R14 | T2R14_HUMAN | TAS2R14 | TRB1 | Taste receptor family B member 1
Type:
n/a
Mol. Mass.:
36183.39
Organism:
Homo sapiens (Human)
Description:
Q9NYV8
Residue:
317
Sequence:
MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
  
Inhibitor
Name:
BDBM50613013
Synonyms:
CHEMBL5285283
Type:
Small organic molecule
Emp. Form.:
C15H12F3NO2
Mol. Mass.:
295.2565
SMILES:
Cc1c(Nc2ccccc2C(O)=O)cccc1C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: