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Target
Peptidyl-prolyl cis-trans isomerase D
Ligand
BDBM50613627
Substrate
n/a
Meas. Tech.
ChEMBL_2292743
Ki
3000±n/a nM
Citation
 Dunyak, BM; Gestwicki, JE Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds. J Med Chem 59:9622-9644 (2016) [PubMed]
Target
Name:
Peptidyl-prolyl cis-trans isomerase D
Synonyms:
40 kDa peptidyl-prolyl cis-trans isomerase | CYP-40 | CYP40 | CYPD | Cyclophilin D (CypD) | Cyclophilin-40 | Cyclophilin-related protein | PPID | PPID_HUMAN | PPIase D | Peptidyl-prolyl cis-trans isomerase D | Rotamase D
Type:
Protein
Mol. Mass.:
40766.62
Organism:
Homo sapiens (Human)
Description:
Q08752
Residue:
370
Sequence:
MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAECGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWEMAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDKEKAVYAKMFA
  
Inhibitor
Name:
BDBM50613627
Synonyms:
CHEMBL2006156
Type:
Small organic molecule
Emp. Form.:
C23H24N4O3
Mol. Mass.:
404.4617
SMILES:
CC(C)N(C(C)C)C(=O)Nc1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Structure:
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