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Target
Pancreatic triacylglycerol lipase
Ligand
BDBM50614084
Substrate
n/a
Meas. Tech.
ChEMBL_2295423
IC50
2800±n/a nM
Citation
 Moghadam Farid, S; Iraji, A; Mojtabavi, S; Ghasemi, M; Faramarzi, MA; Mahdavi, M; Barazandeh Tehrani, M; Akbarzadeh, T; Saeedi, M Quinazolinone-1,2,3-triazole-acetamide conjugates as potent ?-glucosidase inhibitors: synthesis, enzyme inhibition, kinetic analysis, and molecular docking study. RSC Med Chem 14:520-533 (2023) [PubMed]
Target
Name:
Pancreatic triacylglycerol lipase
Synonyms:
LIPP_HUMAN | PL | PNLIP | Pancreatic lipase
Type:
PROTEIN
Mol. Mass.:
51157.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_527250
Residue:
465
Sequence:
MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC
  
Inhibitor
Name:
BDBM50614084
Synonyms:
CHEMBL4128298
Type:
Small organic molecule
Emp. Form.:
C27H19BrN4O5
Mol. Mass.:
559.368
SMILES:
Brc1ccc(Cc2nc3ccccc3c(=O)n2CC(=O)NNC(=O)c2cc3ccccc3oc2=O)cc1
Structure:
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