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Target
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Ligand
BDBM50614174
Substrate
n/a
Meas. Tech.
ChEMBL_2295983
IC50
>10000±n/a nM
Citation
 Davis-Gilbert, ZW; Krämer, A; Dunford, JE; Howell, S; Senbabaoglu, F; Wells, CI; Bashore, FM; Havener, TM; Smith, JL; Hossain, MA; Oppermann, U; Drewry, DH; Axtman, AD Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2. ACS Med Chem Lett 14:432-441 (2023) [PubMed]
Target
Name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Synonyms:
KIAA0589 | PI51C_HUMAN | PIP5K1-gamma | PIP5K1C | PIP5KIgamma | Phosphatidylinositol 4-phosphate 5-kinase type I gamma | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | PtdIns(4)P-5-kinase 1 gamma
Type:
PROTEIN
Mol. Mass.:
73241.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508846
Residue:
668
Sequence:
MELEVPDEAESAEAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPASDGESDT
  
Inhibitor
Name:
BDBM50614174
Synonyms:
CHEMBL5267348
Type:
Small organic molecule
Emp. Form.:
C20H15N3O2
Mol. Mass.:
329.352
SMILES:
OC(=O)c1ccc2c(c1)nc(NCc1ccccc1)c1ncccc21
Structure:
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