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Target
Signal transducer and activator of transcription 6
Ligand
BDBM50614612
Substrate
n/a
Meas. Tech.
ChEMBL_2297943
IC50
20±n/a nM
Citation
 Seipp, K; Groß, J; Kiefer, AM; Erkel, G; Opatz, T Total Synthesis and Biological Evaluation of the Anti-Inflammatory (13 J Nat Prod 86:924-938 (2023) [PubMed]
Target
Name:
Signal transducer and activator of transcription 6
Synonyms:
STAT6 | STAT6_HUMAN
Type:
PROTEIN
Mol. Mass.:
94129.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_881634
Residue:
847
Sequence:
MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW
  
Inhibitor
Name:
BDBM50614612
Synonyms:
CHEMBL5280678
Type:
Small organic molecule
Emp. Form.:
C18H21ClO5
Mol. Mass.:
352.809
SMILES:
C[C@H]1CC\C=C(C)\C(=O)c2c(O)cc(O)c(Cl)c2CC(=O)O[C@@H]1C |r,c:4|
Structure:
Search PDB for entries with ligand similarity: