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Target
Mothers against decapentaplegic homolog 2
Ligand
BDBM50614612
Substrate
n/a
Meas. Tech.
ChEMBL_2297944
IC50
90±n/a nM
Citation
 Seipp, K; Groß, J; Kiefer, AM; Erkel, G; Opatz, T Total Synthesis and Biological Evaluation of the Anti-Inflammatory (13 J Nat Prod 86:924-938 (2023) [PubMed]
Target
Name:
Mothers against decapentaplegic homolog 2
Synonyms:
JV18-1 | MAD homolog 2 | MADH2 | MADR2 | Mad-related protein 2 | Mothers against DPP homolog 2 | Mothers against decapentaplegic homolog 2 | SMAD 2 | SMAD family member 2 | SMAD2 | Smad2 | hMAD-2 | hSMAD2
Type:
PROTEIN
Mol. Mass.:
52306.05
Organism:
Homo sapiens
Description:
ChEMBL_117148
Residue:
467
Sequence:
MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
  
Inhibitor
Name:
BDBM50614612
Synonyms:
CHEMBL5280678
Type:
Small organic molecule
Emp. Form.:
C18H21ClO5
Mol. Mass.:
352.809
SMILES:
C[C@H]1CC\C=C(C)\C(=O)c2c(O)cc(O)c(Cl)c2CC(=O)O[C@@H]1C |r,c:4|
Structure:
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