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Target
Dual specificity mitogen-activated protein kinase kinase 7
Ligand
BDBM50615125
Substrate
n/a
Meas. Tech.
ChEMBL_2299692
IC50
3000±n/a nM
Citation
 Kim, DR; Orr, MJ; Kwong, AJ; Deibler, KK; Munshi, HH; Bridges, CS; Chen, TJ; Zhang, X; Lacorazza, HD; Scheidt, KA Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett 14:606-613 (2023) [PubMed]
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 7
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4
Type:
Protein
Mol. Mass.:
47502.52
Organism:
Homo sapiens (Human)
Description:
O14733
Residue:
419
Sequence:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
  
Inhibitor
Name:
BDBM50615125
Synonyms:
CHEMBL5274709
Type:
Small organic molecule
Emp. Form.:
C20H15ClF4N4O2
Mol. Mass.:
454.805
SMILES:
Fc1ccc(CNc2cc(Oc3cccc(NC(=O)CCl)c3)ncn2)cc1C(F)(F)F
Structure:
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