Reaction Details  Report a problem with these data
Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Ligand
BDBM50615192
Substrate
n/a
Meas. Tech.
ChEMBL_2299891
IC50
1900±n/a nM
Citation
 Willems, HMG; Edwards, S; Boffey, HK; Chawner, SJ; Green, C; Romero, T; Winpenny, D; Skidmore, J; Clarke, JH; Andrews, SP Identification of ARUK2002821 as an isoform-selective PI5P4K? inhibitor. RSC Med Chem 14:934-946 (2023) [PubMed]
Target
Name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Synonyms:
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha | 2.7.1.149 | Diphosphoinositide kinase 2-alpha | PI(5)P 4-kinase type II alpha | PI42A_HUMAN | PI5P4KA | PIP4K2A | PIP4KII-alpha | PIP5K2 | PIP5K2A | PIP5KIII | Phosphatidylinositol 5-phosphate 4-kinase type II alpha | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha | PtdIns(4)P-5-kinase B isoform | PtdIns(4)P-5-kinase C isoform | PtdIns(5)P-4-kinase isoform 2-alpha
Type:
PROTEIN
Mol. Mass.:
46228.59
Organism:
Homo sapiens
Description:
ChEMBL_104274
Residue:
406
Sequence:
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
  
Inhibitor
Name:
BDBM50615192
Synonyms:
CHEMBL4284012
Type:
Small organic molecule
Emp. Form.:
C20H15N3
Mol. Mass.:
297.3532
SMILES:
N#CC(Cc1cccc2cnccc12)c1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: