Reaction Details  Report a problem with these data
Target
Fatty acid-binding protein, adipocyte
Ligand
BDBM50152880
Substrate
n/a
Meas. Tech.
ChEMBL_2301979
IC50
600±n/a nM
Citation
 Floresta, G; Pistarà, V; Amata, E; Dichiara, M; Marrazzo, A; Prezzavento, O; Rescifina, A Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review. Eur J Med Chem 138:854-873 (2017) [PubMed]
Target
Name:
Fatty acid-binding protein, adipocyte
Synonyms:
A-FABP | AFABP | ALBP | Adipocyte lipid-binding protein | FABP4 | FABP4_HUMAN | Fatty acid binding protein adipocyte | Fatty acid-binding protein 4 | Fatty acid-binding protein 4 (FABP4)
Type:
Enzyme
Mol. Mass.:
14719.23
Organism:
Homo sapiens (Human)
Description:
P15090
Residue:
132
Sequence:
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA
  
Inhibitor
Name:
BDBM50152880
Synonyms:
2-(4-Methoxy-benzylsulfanyl)-6-trifluoromethyl-pyrimidin-4-ol | CHEMBL184136
Type:
Small organic molecule
Emp. Form.:
C13H11F3N2O2S
Mol. Mass.:
316.299
SMILES:
COc1ccc(CSc2nc(cc(=O)[nH]2)C(F)(F)F)cc1
Structure:
Search PDB for entries with ligand similarity: