Reaction Details  Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50277609
Substrate
n/a
Meas. Tech.
ChEMBL_2302589
IC50
700000±n/a nM
Citation
 Kaur, R; Dahiya, L; Kumar, M Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus. Eur J Med Chem 141:473-505 (2017) [PubMed]
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50277609
Synonyms:
CHEMBL507312 | [5-(6-Amino-9-isobutyl-2-methylsulfanyl-9H-purin-8-yl)-furan-2-yl]-phosphonic Acid
Type:
Small organic molecule
Emp. Form.:
C14H18N5O4PS
Mol. Mass.:
383.363
SMILES:
CSc1nc(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c2n1
Structure:
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