Reaction Details  Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50203471
Substrate
n/a
Meas. Tech.
ChEMBL_438238 (CHEMBL887347)
Ki
139±n/a nM
Citation
 Carato, P; Graulich, A; Jensen, N; Roth, BL; Liégeois, JF Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors. Bioorg Med Chem Lett 17:1565-9 (2007) [PubMed]  Article
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50203471
Synonyms:
CHEMBL388620 | N-(1-phenethylpiperidin-4-yl)-2-naphthamide
Type:
Small organic molecule
Emp. Form.:
C24H26N2O
Mol. Mass.:
358.476
SMILES:
O=C(NC1CCN(CCc2ccccc2)CC1)c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: