Reaction Details  Report a problem with these data
Target
C-C chemokine receptor type 8
Ligand
BDBM50203925
Substrate
n/a
Meas. Tech.
ChEMBL_425772 (CHEMBL855762)
Ki
7.2±n/a nM
Citation
 Jenkins, TJ; Guan, B; Dai, M; Li, G; Lightburn, TE; Huang, S; Freeze, BS; Burdi, DF; Jacutin-Porte, S; Bennett, R; Chen, W; Minor, C; Ghosh, S; Blackburn, C; Gigstad, KM; Jones, M; Kolbeck, R; Yin, W; Smith, S; Cardillo, D; Ocain, TD; Harriman, GC Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8. J Med Chem 50:566-84 (2007) [PubMed]  Article
Target
Name:
C-C chemokine receptor type 8
Synonyms:
CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2
Type:
PROTEIN
Mol. Mass.:
40855.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_454278
Residue:
355
Sequence:
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
  
Inhibitor
Name:
BDBM50203925
Synonyms:
CHEMBL374979 | N-[4-(1-cyclopropanecarbonyl-piperidin-4-ylsulfamoyl)-naphthalen-1-yl]-2-methyl-benzamide
Type:
Small organic molecule
Emp. Form.:
C27H29N3O4S
Mol. Mass.:
491.602
SMILES:
Cc1ccccc1C(=O)Nc1ccc(c2ccccc12)S(=O)(=O)NC1CCN(CC1)C(=O)C1CC1
Structure:
Search PDB for entries with ligand similarity: