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Target
Coagulation factor X
Ligand
BDBM50209891
Substrate
n/a
Meas. Tech.
ChEMBL_443802 (CHEMBL892965)
IC50
10±n/a nM
Citation
 Ishihara, T; Seki, N; Hirayama, F; Orita, M; Koshio, H; Taniuchi, Y; Sakai-Moritani, Y; Iwatsuki, Y; Kaku, S; Kawasaki, T; Matsumoto, Y; Tsukamoto, S Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors. Bioorg Med Chem 15:4175-92 (2007) [PubMed]  Article
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50209891
Synonyms:
CHEMBL390266 | [(((E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl){1-[(2,5-dimethoxyphenyl)sulfonyl]piperidin-4-yl}-amino)sulfonyl]acetic acid
Type:
Small organic molecule
Emp. Form.:
C25H32N4O8S2
Mol. Mass.:
580.674
SMILES:
COc1ccc(OC)c(c1)S(=O)(=O)N1CCC(CC1)N(C\C=C\c1cccc(c1)C(N)=N)S(=O)(=O)CC(O)=O
Structure:
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