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Target
B1 bradykinin receptor
Ligand
BDBM50210366
Substrate
n/a
Meas. Tech.
ChEMBL_443978 (CHEMBL893140)
Ki
1451±n/a nM
Citation
 Su, DS; Lim, JL; Markowitz, MK; Wan, BL; Murphy, KL; Reiss, DR; Harrell, CM; O'Malley, SS; Ransom, RW; Chang, RS; Pettibone, DJ; Tang, C; Prueksaritanont, T; Freidinger, RM; Bock, MG Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes. Bioorg Med Chem Lett 17:3006-9 (2007) [PubMed]  Article
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50210366
Synonyms:
3,3,3-trifluoro-N-(2-((4-methoxy-4-phenylcyclohexyl)methylamino)pyridin-3-yl)propanamide | CHEMBL389094
Type:
Small organic molecule
Emp. Form.:
C22H26F3N3O2
Mol. Mass.:
421.4559
SMILES:
COC1(CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1)c1ccccc1 |(28.61,6.75,;29.45,5.45,;28.74,4.08,;28.74,2.54,;27.4,1.77,;26.07,2.54,;24.74,1.77,;24.74,.23,;23.4,-.54,;23.4,-2.08,;22.07,-2.85,;20.74,-2.08,;20.74,-.54,;22.07,.23,;22.07,1.77,;20.74,2.54,;19.4,1.77,;20.74,4.08,;19.4,4.85,;18.06,5.63,;20.17,6.19,;18.64,3.52,;26.07,4.08,;27.4,4.85,;30.07,3.32,;30.08,1.78,;31.42,1.02,;32.76,1.8,;32.75,3.33,;31.41,4.09,)|
Structure:
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