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Target
Beta-lactamase
Ligand
BDBM50211049
Substrate
n/a
Meas. Tech.
ChEMBL_434809 (CHEMBL917037)
IC50
20000±n/a nM
Citation
 Feng, BY; Simeonov, A; Jadhav, A; Babaoglu, K; Inglese, J; Shoichet, BK; Austin, CP A high-throughput screen for aggregation-based inhibition in a large compound library. J Med Chem 50:2385-90 (2007) [PubMed]  Article
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC
Type:
Protien
Mol. Mass.:
41561.62
Organism:
Escherichia coli
Description:
P00811
Residue:
377
Sequence:
MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ
  
Inhibitor
Name:
BDBM50211049
Synonyms:
CHEMBL227512 | N-(4-(2,3,5,6-tetrafluoro-4-methoxybenzamido)phenyl)furan-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C19H12F4N2O4
Mol. Mass.:
408.3032
SMILES:
COc1c(F)c(F)c(C(=O)Nc2ccc(NC(=O)c3ccco3)cc2)c(F)c1F
Structure:
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