Reaction Details  Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50214146
Substrate
n/a
Meas. Tech.
ChEMBL_456282 (CHEMBL888296)
IC50
100±n/a nM
Citation
 Pégurier, C; Collart, P; Danhaive, P; Defays, S; Gillard, M; Gilson, F; Kogej, T; Pasau, P; Van Houtvin, N; Van Thuyne, M; van Keulen, B Pyrazolone methylamino piperidine derivatives as novel CCR3 antagonists. Bioorg Med Chem Lett 17:4228-31 (2007) [PubMed]  Article
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50214146
Synonyms:
4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)piperidin-4-yl)amino)methyl)-2-(4-(dimethylamino)phenyl)-1,5-dimethyl-1,2-dihydropyrazol-3-one | CHEMBL394443
Type:
Small organic molecule
Emp. Form.:
C34H38ClF2N5O2
Mol. Mass.:
622.148
SMILES:
CN(C)c1ccc(cc1)-n1n(C)c(C)c(CN(CCc2ccc(Cl)cc2)C2CCN(CC2)C(=O)c2c(F)cccc2F)c1=O
Structure:
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