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Target
Bone morphogenetic protein 1
Ligand
BDBM50216798
Substrate
n/a
Meas. Tech.
ChEMBL_440136 (CHEMBL890447)
IC50
36±n/a nM
Citation
 Fish, PV; Allan, GA; Bailey, S; Blagg, J; Butt, R; Collis, MG; Greiling, D; James, K; Kendall, J; McElroy, A; McCleverty, D; Reed, C; Webster, R; Whitlock, GA Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J Med Chem 50:3442-56 (2007) [PubMed]  Article
Target
Name:
Bone morphogenetic protein 1
Synonyms:
BMP-1 | BMP1 | BMP1_HUMAN | Mammalian tolloid protein | PCOLC | PCP | Procollagen C-proteinase | mTld
Type:
PROTEIN
Mol. Mass.:
111254.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_518962
Residue:
986
Sequence:
MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK
  
Inhibitor
Name:
BDBM50216798
Synonyms:
(R)-ethyl 5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxylate | CHEMBL374840
Type:
Small organic molecule
Emp. Form.:
C17H27N3O5
Mol. Mass.:
353.4134
SMILES:
CCOC(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO |r|
Structure:
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