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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50219024
Substrate
n/a
Meas. Tech.
ChEMBL_445279 (CHEMBL893404)
Ki
34±n/a nM
Citation
 Jiang, Y; Chen, CA; Lu, K; Daniewska, I; De Leon, J; Kong, R; Forray, C; Li, B; Hegde, LG; Wolinsky, TD; Craig, DA; Wetzel, JM; Andersen, K; Marzabadi, MR Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit. J Med Chem 50:3870-82 (2007) [PubMed]  Article
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39075.64
Organism:
RAT
Description:
Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:
353
Sequence:
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50219024
Synonyms:
2-methyl-N-{4-methyl-3-[1-(3-{[(2R)-2-phenylpropanoyl]-amino}propyl)-4-piperidinyl]phenyl}propanamide | CHEMBL242053
Type:
Small organic molecule
Emp. Form.:
C28H39N3O2
Mol. Mass.:
449.6282
SMILES:
CC(C)C(=O)Nc1ccc(C)c(c1)C1CCN(CCCNC(=O)[C@@H](C)c2ccccc2)CC1
Structure:
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