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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50219049
Substrate
n/a
Meas. Tech.
ChEMBL_445301 (CHEMBL894442)
Ki
350±n/a nM
Citation
 Chen, CA; Jiang, Y; Lu, K; Daniewska, I; Mazza, CG; Negron, L; Forray, C; Parola, T; Li, B; Hegde, LG; Wolinsky, TD; Craig, DA; Kong, R; Wetzel, JM; Andersen, K; Marzabadi, MR Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits. J Med Chem 50:3883-90 (2007) [PubMed]  Article
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39075.64
Organism:
RAT
Description:
Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:
353
Sequence:
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50219049
Synonyms:
1-(4-Chloro-phenyl)-4-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-butan-1-one | 1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)butan-1-one | CHEMBL363548
Type:
Small organic molecule
Emp. Form.:
C21H23Cl2NO2
Mol. Mass.:
392.319
SMILES:
OC1(CCN(CCCC(=O)c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1
Structure:
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