Reaction Details  Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50222167
Substrate
n/a
Meas. Tech.
ChEMBL_449846 (CHEMBL897910)
Ki
1070±n/a nM
Citation
 Hernández, AS; Cheng, PT; Musial, CM; Swartz, SG; George, RJ; Grover, G; Slusarchyk, D; Seethala, RK; Smith, M; Dickinson, K; Giupponi, L; Longhi, DA; Flynn, N; Murphy, BJ; Gordon, DA; Biller, SA; Robl, JA; Tino, JA Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues. Bioorg Med Chem Lett 17:5928-33 (2007) [PubMed]  Article
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50222167
Synonyms:
2-amino-N-{(S)-1-[1-(2-benzylcarbamoyl-ethyl)-1H-tetrazol-5-yl]-2-benzyloxy-ethyl}-2-methyl-propionamide | CHEMBL393321
Type:
Small organic molecule
Emp. Form.:
C24H31N7O3
Mol. Mass.:
465.548
SMILES:
CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1
Structure:
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