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Target
B1 bradykinin receptor
Ligand
BDBM50222679
Substrate
n/a
Meas. Tech.
ChEMBL_446484 (CHEMBL895596)
IC50
1600±n/a nM
Citation
 Dressen, D; Garofalo, AW; Hawkinson, J; Hom, D; Jagodzinski, J; Marugg, JL; Neitzel, ML; Pleiss, MA; Szoke, B; Tung, JS; Wone, DW; Wu, J; Zhang, H Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin B1 receptor antagonists. J Med Chem 50:5161-7 (2007) [PubMed]  Article
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50222679
Synonyms:
4-bromo-5-(2-chlorobenzoylamino)-1-(2-dimethylaminoethyl)-1H-pyrazole-3-carboxylic acid [2-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)ethyl]amide | CHEMBL244284
Type:
Small organic molecule
Emp. Form.:
C27H33BrClN7O2
Mol. Mass.:
602.954
SMILES:
CN(C)CCn1nc(C(=O)NCCC2CCN(CC2)c2ccncc2)c(Br)c1NC(=O)c1ccccc1Cl
Structure:
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