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Target
Urotensin-2 receptor
Ligand
BDBM50224727
Substrate
n/a
Meas. Tech.
ChEMBL_450868 (CHEMBL899954)
IC50
210±n/a nM
Citation
 Luci, DK; Ghosh, S; Smith, CE; Qi, J; Wang, Y; Haertlein, B; Parry, TJ; Li, J; Almond, HR; Minor, LK; Damiano, BP; Kinney, WA; Maryanoff, BE; Lawson, EC Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment. Bioorg Med Chem Lett 17:6489-92 (2007) [PubMed]  Article
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | Gpr14 | Senr | UR-II-R | UR2R_RAT | Urotensin-II | Uts2r
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42725.34
Organism:
RAT
Description:
Urotensin-II UTS2R RAT::P49684
Residue:
386
Sequence:
MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
  
Inhibitor
Name:
BDBM50224727
Synonyms:
CHEMBL239199 | N-benzyl-4-((5-chloro-2-(1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)ethyl)piperidin-4-yl)benzamido)methyl)piperidine-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C36H42ClN5O4
Mol. Mass.:
644.203
SMILES:
Clc1ccc(C2CCN(CCN3C(=O)COc4ccccc34)CC2)c(c1)C(=O)NCC1CCN(CC1)C(=O)NCc1ccccc1
Structure:
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