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Target
Vasopressin V1a receptor
Ligand
BDBM50225175
Substrate
n/a
Meas. Tech.
ChEMBL_458590 (CHEMBL942873)
IC50
100±n/a nM
Citation
 Xiang, MA; Rybczynski, PJ; Patel, M; Chen, RH; McComsey, DF; Zhang, HC; Gunnet, JW; Look, R; Wang, Y; Minor, LK; Zhong, HM; Villani, FJ; Demarest, KT; Damiano, BP; Maryanoff, BE Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies. Bioorg Med Chem Lett 17:6623-8 (2007) [PubMed]  Article
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM50225175
Synonyms:
CHEMBL248733 | N-(3-chloro-4-{[3'-(hydroxymethyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-en-1-yl]carbonyl}phenyl)-5-fluoro-2-methylbenzamide
Type:
Small organic molecule
Emp. Form.:
C30H28ClFN2O3
Mol. Mass.:
519.006
SMILES:
Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(CCC(CO)=C3)Cc3ccccc23)c(Cl)c1 |w:20.27,c:26|
Structure:
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