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Target
Coagulation factor X
Ligand
BDBM50228954
Substrate
n/a
Meas. Tech.
ChEMBL_461718 (CHEMBL928849)
Ki
0.4±n/a nM
Citation
 Young, RJ; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chan, C; Charbaut, M; Chung, CW; Convery, MA; Kelly, HA; Paul King, N; Kleanthous, S; Mason, AM; Pateman, AJ; Patikis, AN; Pinto, IL; Pollard, DR; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs. Bioorg Med Chem Lett 18:23-7 (2008) [PubMed]  Article
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50228954
Synonyms:
(E)-2-(6-(3-(2-(5-chlorothiophen-2-yl)vinylsulfonamido)-2-oxopyrrolidin-1-yl)pyridin-3-yl)-N,N-dimethylbenzenesulfonamide | CHEMBL254543
Type:
Small organic molecule
Emp. Form.:
C23H23ClN4O5S3
Mol. Mass.:
567.101
SMILES:
CN(C)S(=O)(=O)c1ccccc1-c1ccc(nc1)N1CCC(NS(=O)(=O)\C=C\c2ccc(Cl)s2)C1=O |w:21.23|
Structure:
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