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Target
C-C chemokine receptor type 2
Ligand
BDBM50231618
Substrate
n/a
Meas. Tech.
ChEMBL_462015 (CHEMBL944858)
IC50
24±n/a nM
Citation
 Pasternak, A; Goble, SD; Vicario, PP; Di Salvo, J; Ayala, JM; Struthers, M; DeMartino, JA; Mills, SG; Yang, L Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists. Bioorg Med Chem Lett 18:994-8 (2008) [PubMed]  Article
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50231618
Synonyms:
CHEMBL401608 | N-(3,5-bis(trifluoromethyl)benzyl)-3-(4-(6-chloropyrimidin-4-yl)piperidin-1-yl)-1-(2-hydroxypropan-2-yl)cyclopentanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C27H31ClF6N4O2
Mol. Mass.:
593.004
SMILES:
CC(C)(O)[C@@]1(CC[C@H](C1)N1CCC(CC1)c1cc(Cl)ncn1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Structure:
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