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Target
Cannabinoid receptor 2
Ligand
BDBM50211843
Substrate
n/a
Meas. Tech.
ChEMBL_462578 (CHEMBL928504)
EC50
63±n/a nM
Citation
 Ermann, M; Riether, D; Walker, ER; Mushi, IF; Jenkins, JE; Noya-Marino, B; Brewer, ML; Taylor, MG; Amouzegh, P; East, SP; Dymock, BW; Gemkow, MJ; Kahrs, AF; Ebneth, A; Löbbe, S; O'Shea, K; Shih, DT; Thomson, D Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity. Bioorg Med Chem Lett 18:1725-9 (2008) [PubMed]  Article
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50211843
Synonyms:
2-(2,4-dichlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid N-(tetrahydropyran-4-ylmethyl)amide | 2-(2,4-dichlorophenylamino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide | CHEMBL225411 | GW-842166 | GW-842166X
Type:
Small organic molecule
Emp. Form.:
C18H17Cl2F3N4O2
Mol. Mass.:
449.254
SMILES:
FC(F)(F)c1nc(Nc2ccc(Cl)cc2Cl)ncc1C(=O)NCC1CCOCC1
Structure:
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