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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50235896
Substrate
n/a
Meas. Tech.
ChEMBL_462870 (CHEMBL928788)
IC50
3.7±n/a nM
Citation
 Liu, C; Lin, J; Pitt, S; Zhang, RF; Sack, JS; Kiefer, SE; Kish, K; Doweyko, AM; Zhang, H; Marathe, PH; Trzaskos, J; Mckinnon, M; Dodd, JH; Barrish, JC; Schieven, GL; Leftheris, K Benzothiazole based inhibitors of p38alpha MAP kinase. Bioorg Med Chem Lett 18:1874-9 (2008) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50235896
Synonyms:
6-(5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl)-N-isopropylbenzo[d]thiazol-2-amine | CHEMBL255470
Type:
Small organic molecule
Emp. Form.:
C19H18FN5S
Mol. Mass.:
367.443
SMILES:
CC(C)Nc1nc2ccc(cc2s1)-c1c(N)[nH]nc1-c1ccccc1F
Structure:
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