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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50236485
Substrate
n/a
Meas. Tech.
ChEMBL_463025 (CHEMBL929949)
IC50
5800±n/a nM
Citation
 Hynes, J; Wu, H; Pitt, S; Shen, DR; Zhang, R; Schieven, GL; Gillooly, KM; Shuster, DJ; Taylor, TL; Yang, X; McIntyre, KW; McKinnon, M; Zhang, H; Marathe, PH; Doweyko, AM; Kish, K; Kiefer, SE; Sack, JS; Newitt, JA; Barrish, JC; Dodd, J; Leftheris, K The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor. Bioorg Med Chem Lett 18:1762-7 (2008) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50236485
Synonyms:
2-(isopropylamino)-N-(2-methyl-5-((1-methyl-1H-pyrazol-5-yl)carbamoyl)phenyl)thiazole-5-carboxamide | CHEMBL258223
Type:
Small organic molecule
Emp. Form.:
C19H22N6O2S
Mol. Mass.:
398.482
SMILES:
CC(C)Nc1ncc(s1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccnn1C
Structure:
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