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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50236484
Substrate
n/a
Meas. Tech.
ChEMBL_463023 (CHEMBL929947)
IC50
36±n/a nM
Citation
 Hynes, J; Wu, H; Pitt, S; Shen, DR; Zhang, R; Schieven, GL; Gillooly, KM; Shuster, DJ; Taylor, TL; Yang, X; McIntyre, KW; McKinnon, M; Zhang, H; Marathe, PH; Doweyko, AM; Kish, K; Kiefer, SE; Sack, JS; Newitt, JA; Barrish, JC; Dodd, J; Leftheris, K The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor. Bioorg Med Chem Lett 18:1762-7 (2008) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50236484
Synonyms:
CHEMBL255428 | N-(2-chloro-6-methylphenyl)-2-(cyclobutylamino)thiazole-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C15H16ClN3OS
Mol. Mass.:
321.825
SMILES:
Cc1cccc(Cl)c1NC(=O)c1cnc(NC2CCC2)s1
Structure:
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